Someone mentioned XML/XSL/FO. Don't try to write your content in XSL-FO. You'll hate every minute of it.
I'd look in to using DITA (Darwin Information Typing Architecture). It's a set of canned XML structures, plus a specification for how to process and customize those structures. It includes tags for stuff like footnotes...I bet it covers a lot of your use cases. There are some good intros to how these XML structures work here: http://dita.xml.org/book/dita-wiki-knowledgebase
As DITA is XML, you can convert it to HTML and whatever else you feel like, pretty easily. There's an open-source implementation of the DITA spec called the DITA Open Toolkit (http://sourceforge.net/projects/dita-ot/). The DITA Open Toolkit includes stylesheets/scripts to publish HTML and PDF, among other things. PDFs are published via XSL-FO. Just like HTML needs a web browser to render something useful, XSL-FO requires a FO processor to create a PDF. So, in the end you write DITA, XSLT and other scripts transform that DITA to XSL-FO, the a FO processor consumes the XSL-FO and spits out a PDF. The DITA Open Toolkit comes with an open-source FO processor (Apache FOP). FOP doesn't fulfill everyone's needs, but it might work very well for you.
Unfortunately, working with the Open Toolkit and customizing its output can be a bit unwieldy. http://groups.yahoo.com/search?query=dita+users is a pretty good place to look for help.
Time for a sequel to Animal Farm. At some point in the story, the paranoid pigs will order a culling of all humans.
Great idea...Bet our energy future on something that's succeptible to FoxDie.
The typical page layout program is nothing more than an electronic light table for cutting and pasting documents.