I dunno. I just don't buy it. The staggering complexity of human behavior, market forces, etc. seems such an obvious, and concrete even, issue that you'd have to be suffering from pathological delusions to be a successful physicist and ignore it. Although, if my understanding is correct, these delusions may be exactly what you're imputing to Nobel prize winners.
I recognize what you're saying as a possibility. However, I also have a suspicion that those who succeed in intellectual endeavors have a great awareness of what they do not know. It's expedient in learning and in problem solving; without having skill in it, it seems unlikely that you'd make much progress in the first place. If there's any truth to this, it's inconceivable to me that someone skilled in locating what they do not know, would make the unforgivable blunder of thinking they know enough about an overly complex system to control it.