I should start this with a disclaimer: I'm the founder of the Hexayurt Project, a Free Hardware building system aimed at refugees and in widespread use at Burning Man. It's those silver pod things (http://hexayurt.com)
I think Wikihouse is exciting technically, but it's *incredibly* expensive to build - something like 7000 EUR of CNC cutting time for a single room. The parametric design aspects of the project are great, however, and I can see a future in which the components are mass produced at reasonable price and then assembled according to plans generated from the parametric design software. But without some kind of standardization, this kind of production is going to remain incurably expensive and therefore just another architectural demo. It's not a technology until costs are estimated. This has happened before: Architecture For Humanity's Open Architecture Network (http://openarchitecturenetwork.org/) rapidly filled with impractical technology demonstrators and student projects - 10000+ designs, but how many practically buildable?
Actually getting buildings that people can build is hard. Architects are trained to think about custom work, one-offs and impressing other architects. Mass producing housing at a price people can afford (hello, Mortage Crisis, goodbye Mortgage Crisis) requires a radical rethink of how we do construction: modularity, prefabrication, standardization - all the same things we did for every other technology we wanted to be cheap, easy and reliable.
It's often said that home building is the last truly-madly-deeply inefficient global industry. Imagine if they built cars by having people come to your garage to hand-assemble them! Whether the radical change is mass manufacture of entire houses Buckminster Fuller style, interchangable modular components (structural insualted panels) or something like 3D printing with insulated concrete, we can't keep buliding houses by hand in a world where everything else is efficiently mass produced with near-zero defects and not distort the shape of our societies.
Hexayurts are dirt cheap and designed for modular mass manufacture. But they look weird. Such is life :-)