Re:Finished my ass (Score 1)

Yes the simple sequence control structures (centromeres and telomeres) are unresolved. There are also some large scale duplications > 1MB that are unresolved. This is as good as it gets with all current technology until we can magically peer at DNA and see the base pairs. However, saying "they are even lacking in the Celera version of the genome" is unintentionally funny cause of course they aren't in the Celera version, the Celera version leaves out all of the hard parts and many of the easy parts already, why would you expect the hardest parts to be resolved in the Celera (unfinished) version? If you NEED to use sequence in areas which has not been assembled or has not been sequenced then perhaps you might consider doing the work yourself for those areas as the funding and interest exist to work on them, instead of relying on someone else to generate the data for you. The HGP was meant to accelerate disease research and it has done so and will continue to do so for most diseases. Do you rememeber when you needed to spend 5 years mapping a trait loci, another 3 years sequencing (poorly) the local region, another 3 years mapping a finer interval, and then being able to construct a linkage SNP study on a population to attempt to identify the disease mutation? Before the sequence was available identifing and cloning a simple Mendalian disease trait was someone's and many grad students life work! You think you could always look up a candidate interval and identify all of the genes in that interval so you could postulate about the disease mechanism? No, 10 years ago you would sitting there with a disease phenotype and no other information, heck, before the HGP you didn't even have a decent human linkage map- these were built as part of the HGP. Before those ~15 years ago, you couldn't even map a disease interval. Anyway I'm all for finished and complete sequence as I push this viewpoint for a living, but there are limits for a reason. So congrats to Sanger and UWASH for finally publishing Chrom1, we've been waiting for a while :)