Apart from the F35's woeful state of _software_ development, the hardware isn't in much better state and the overall design has been so hopelessly compromised by conflicting demands that it's outclassed by just about every other aircraft it will run up against. In particular its missile evasion relies almost entirely on stealth, which it only possesses in a front-on aspect.
Don't forget that it was designed and intended to be used in situations where all enemy airpower has been neutralised or rendered ineffective by the F22 and the remaining threats are lower tech.
The F35 is an air-support weapon. It was _never_ intended to be an air superiority fighter. Going up against aircraft which are designed for that task, operated by an enemy whose ground-detection equipment hasn't been wiped out will be a fairly short encounter and not in the F35's favour.
The problem is that it's now being pitched to internationally as an air superiority fighter. Once the insurmountable shortcomings in that role become apparent, most client airforces will simply cancel their orders and buy something else.
The cost of building, flying and maintaining this aircraft is so high that all most enemies need to do is simply let the US continue to do so and let it bankrupt itself. The country is already spending so much of its GDP on military expenditure that it's suffering from hopelessly compromised infrastructure due to lack of maintenance (Think: Brazil - the film) and has further weakened its education to maintain the military spend. This, coupled with rampant and increasingly blatant state-level corruption is likely to lead to an economic collapse which will make 2008 look minor.
And that's quite apart from how bad things could get if an oversized Chucky doll operated by the tribble sitting on its head manages to get to the top office.
The F35 is likely to spend its days as an electronics truck, flying comms platform (if they can solve the cooling problems) supporting other aircraft and growler, despite its stupidly high fuel consumption, simply to have a justification to keep it. The program is so deeply embedded into military budgets that unlike the similarly disasterous F111B, it can't easily be cancelled - bringing up that whilst the hardware and design lessons from the F111B brought forth the F14 and F15, the political ones brought forth plans to ensure your program can't be killed.
The F35 is widely known as "The plane which could eat the pentagon" and at the current rate of events that is likely to happen.
Remember that one of their fundamental weak points of the Nazis and the thing which caused their ultimate wartime failure was undue concentration on higher technology and "better weapons", where the cost of those things was so high that their numbers were hopelessly limited and in any case critically dependent on vulnerable supply chains.
I point you to http://www.mayofamily.com/RLM/...