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Comment Re:NPR lost the plot on this article (Score 1) 43

There is minuscule public (non-insider) information about medical trials.

Typically there's quite a bit. "New" drugs usually have quite a bit of published pre-clinical work, sometimes going back decades, and previous phase clinical trials must be published.

This is "gambling".

Yes. All all the justifications Kalshi came up with are bullshit. Either things that already exist in a non-gambling form (e.g. clinicaltrials.gov) or are not useful.

Comment Re:But...they share the same DNA building blocks (Score 2) 84

The canonical RNA bases are conserved between branches of life, but the modified versions vary quite a bit, and quite a few of them are kingdom-specific. Substituting pseudouridine isn't something we invented, for example, it's pretty common in archea.

The DNA bases seem to be universal. We've created synthetic base pairs that seem to work okay, but we're also just barely starting to build the first beginnings of a metabolism on them so we're a long way from showing that they do more than pair up appropriately.

Anyway, the story is about metabolism rather than genetic code. The summary is dumb.

Comment Re:I worked on self driving software (Score 1) 208

My concerns with cameras were dirty lenses and limited dynamic range.

The first is pretty easy to fix with more cameras, or the same technology we use to solve it for humans (wipers). LIDAR is also vulnerable to dirty lenses, both on the emitter and receiver.

The second is an imaginary problem: human eyes and modern cameras have about the same dynamic range. The human eye fakes high dynamic range the same way we do it with cameras: taking multiple exposures. And the camera can do it faster.

I think LIDAR became popular with autonomous car developers because it was off the shelf when they started and it gives a nice clear single-sensor direction + distance measurement. LIDAR's big problem is that it's serial. Waymo's LIDAR apparently has a refresh rate of about 10 Hz, which is pretty scary if you've ever played a racing game at 10 FPS. It's also mechanical, which isn't great. They also don't talk about the resolution, probably for good reason.

Automotive LIDAR's big advantages are that near IR can penetrate fog a bit better than visible, you get a depth measurement that's not dependent on the limited baseline you have in a car. But you can make a camera that's sensitive to the wavelengths used by automotive LIDAR pretty easily. You can also make time of flight cameras, again pretty easily. And those cameras are full parallel devices with no moving parts and as many FPS as you care to pay for. They also don't require shooting lasers around, although you can if you want to.

Comment Re: The same problem as AI (Score 1) 208

Sure it does. Example: https://en.wikipedia.org/wiki/...

Dispensing with the silly absolutism, we're talking about driving. If you can't see well enough to drive safely then you should absolutely stop or slow down enough that you can. If you don't, life might stop. Example:

https://abc7chicago.com/post/m...

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