Spatial CIELAB (Score 3, Informative)

One problem might be that color perception depends on the spatial structure of the scene as well as the pure CIELAB coordinates. At least one research group has taken a stab at including spatial information into a model of image quality. Take a look at
http://white.stanford.edu/~brian/scielab/scielab .h tml

vischeck.com also have an interesting take on simulating color deficiencies (although not the perceptual differences between 'regular' colors). 'Color blind' might be interested in this.