Early waves of Covid, before the vaccines, caused blood clots throughout the body. In radiology, we saw blood clots in the small vessels of the lungs & brain. Organ-Specific Impacts:

• In the Lungs: Early autopsy and high-resolution imaging data confirmed that severe respiratory failure wasn't just caused by typical ARDS cellular damage, but by pulmonary microvascular thrombosis cutting off gas exchange entirely.
• In the Brain: Beyond macrovascular ischemic strokes, microthrombi in the cerebral microvasculature compromised the blood-brain barrier. This resulted in diffuse micro-bleeds, localized hypoperfusion, and intense neuroinflammation, which directly correlates with the severe acute encephalopathy and persistent cognitive deficits observed clinically.

The shift away from high rates of severe, widespread microvascular clotting occurred primarily between late 2021 and early 2022, driven by the sequential arrivals of the Delta and Omicron variants alongside widespread population immunity. While early-wave infections frequently presented as a devastating systemic clotting disorder, a multi-phase transition drastically reduced both the incidence and scale of thrombotic complications. [1], [2], [3], [4] Phase 1: Mid-2021 (The Delta Wave & Early Vaccination) By the time the Delta variant became dominant in the summer of 2021, mass vaccination campaigns had significantly altered clinical presentation. [3], [5]

• 70%+ Risk Reduction: Large clinical cohorts showed that vaccinated individuals who experienced breakthrough infections had up a 72% reduction in venous thromboembolism (VTE) risk compared to unvaccinated patients. [6]
• Matured Hospital Protocols: By mid-2021, frontline clinicians had abandoned early mechanical ventilation strategies in favor of aggressive, early prophylactic anticoagulation protocols (using low-molecular-weight heparin) upon patient admission, halting the progression of microthrombi before they could overwhelm the vascular bed.

Phase 2: Early 2022 (The Omicron Shift) The true evolutionary tipping point for how the virus interacted with human blood vessels arrived with the Omicron variant in late 2021 and early 2022. [4]

• Altered Tissue Tropism: Omicron shifted its primary entry mechanism. It focused its infection heavily on the upper respiratory tract rather than the deep, ACE2-rich endothelial cells of the lower lungs. This change largely spared the pulmonary microvasculature from direct endothelial invasion (endotheliitis). [2], [4]
• Fewer Central Clots: Multicenter radiology audits tracking pulmonary embolisms noted a distinct structural change during Omicron. The massive, life-threatening "saddle" or central large-vessel filling defects highly prevalent in 2020 transitioned mostly to isolated peripheral, small subsegmental clots that carried a much lower mortality rate. [4]

The Baseline Today While the acute risk of widespread microvascular collapse has fundamentally stabilized, the virus has not completely lost its thrombogenic edge. Large database reviews, including studies tracked by the CDC, confirm that patients diagnosed with COVID-19 still experience a roughly 73% increased risk of a thrombotic event in the year following their illness when compared to patients infected with other acute respiratory infections like influenza. The difference today is that the risk is an incremental, post-acute vascular vulnerability rather than the catastrophic, acute microvascular clotting that defined the pre-vaccine era. [7], [8] References:

1. PMC10123679 (Early Wave Autopsy/Imaging Data)
2. ASH Clinical News (New Strains & VTE Risk)
3. PMC9188439 (Delta & Vaccination Clinical Cohorts)
4. PMC12453200 (Omicron Radiological Audits)
5. BBC News (UK Population Immunity & Variant Shifting)
6. CIDRAP (Vaccine VTE Risk Reduction Study)
7. Open Forum Infectious Diseases (Post-Acute Vascular Vulnerability)
8. CDC Emerging Infectious Diseases (COVID-19 vs Influenza Thrombotic Risk)

Early waves of Covid, before the vaccines, caused blood clots throughout the body. In radiology, we saw blood clots in the small vessels of the lungs & brain. Organ-Specific Impacts: In the Lungs: Early autopsy and high-resolution imaging data confirmed that severe respiratory failure wasn't just caused by typical ARDS cellular damage, but by pulmonary microvascular thrombosis cutting off gas exchange entirely. In the Brain: Beyond macrovascular ischemic strokes, microthrombi in the cerebral microvasculature compromised the blood-brain barrier. This resulted in diffuse micro-bleeds, localized hypoperfusion, and intense neuroinflammation, which directly correlates with the severe acute encephalopathy and persistent cognitive deficits observed clinically. The shift away from high rates of severe, widespread microvascular clotting occurred primarily between late 2021 and early 2022, driven by the sequential arrivals of the Delta and Omicron variants alongside widespread population immunity. While early-wave infections frequently presented as a devastating systemic clotting disorder, a multi-phase transition drastically reduced both the incidence and scale of thrombotic complications. [1, 2, 3, 4] ## Phase 1: Mid-2021 (The Delta Wave & Early Vaccination) By the time the Delta variant became dominant in the summer of 2021, mass vaccination campaigns had significantly altered clinical presentation. [3, 5] * 70%+ Risk Reduction: Large clinical cohorts showed that vaccinated individuals who experienced breakthrough infections had up a [72% reduction in venous thromboembolism (VTE) risk](https://www.cidrap.umn.edu/covid-19/vaccines-cut-risk-post-covid-heart-failure-blood-clots-least-6-months-data-suggest) compared to unvaccinated patients. [6] * Matured Hospital Protocols: By mid-2021, frontline clinicians had abandoned early mechanical ventilation strategies in favor of aggressive, early prophylactic anticoagulation protocols (using low-molecular-weight heparin) upon patient admission, halting the progression of microthrombi before they could overwhelm the vascular bed. ## Phase 2: Early 2022 (The Omicron Shift) The true evolutionary tipping point for how the virus interacted with human blood vessels arrived with the Omicron variant in late 2021 and early 2022. [4] * Altered Tissue Tropism: Omicron shifted its primary entry mechanism. It focused its infection heavily on the upper respiratory tract rather than the deep, ACE2-rich endothelial cells of the lower lungs. This change largely spared the pulmonary microvasculature from direct endothelial invasion (endotheliitis). [2, 4] * Fewer Central Clots: Multicenter radiology audits tracking pulmonary embolisms noted a distinct structural change during Omicron. The massive, life-threatening "saddle" or central large-vessel filling defects highly prevalent in 2020 transitioned mostly to [isolated peripheral, small subsegmental clots](https://pmc.ncbi.nlm.nih.gov/articles/PMC12453200/) that carried a much lower mortality rate. [4] ## The Baseline Today While the acute risk of widespread microvascular collapse has fundamentally stabilized, the virus has not completely lost its thrombogenic edge. Large database reviews, including studies tracked by the [CDC](https://wwwnc.cdc.gov/eid/article/31/14/25-0630_article), confirm that patients diagnosed with COVID-19 still experience a roughly 73% increased risk of a thrombotic event in the year following their illness when compared to patients infected with other acute respiratory infections like influenza. The difference today is that the risk is an incremental, post-acute vascular vulnerability rather than the catastrophic, acute microvascular clotting that defined the pre-vaccine era. [7, 8] [1] [https://pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC10123679/) [2] [https://ashpublications.org](https://ashpublications.org/ashclinicalnews/news/6786/New-Strains-Vaccination-Bring-Lower-Risk-of-VTE) [3] [https://pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC9188439/) [4] [https://pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC12453200/) [5] [https://www.bbc.com](https://www.bbc.com/news/health-61010090) [6] [https://www.cidrap.umn.edu](https://www.cidrap.umn.edu/covid-19/vaccines-cut-risk-post-covid-heart-failure-blood-clots-least-6-months-data-suggest) [7] [https://academic.oup.com](https://academic.oup.com/ofid/article/11/11/ofae557/7765956) [8] [https://wwwnc.cdc.gov](https://wwwnc.cdc.gov/eid/article/31/14/25-0630_article)

With predominantly regenerative braking, the actual brakes on an EV are barely used. This is yet another reason to drive EVs.

Quite frankly, the agencyâ(TM)s decision buggers belief.

This sounds completely reasonable to low information GOP and undecided voters who don't know anything about how Congress, laws, delegation, federal agencies, regulation, or courts work. Thanks for parroting those talking points.

Thanks for the breakdown, Justice Roberts!

Because some of us enjoy not being robbed.

College students def have 20m / 30m per week to charge an EV. (Source, did college, had plenty to study, would have been happy to have a Tesla).

Disastrously incompetent Republican mismanagement of the isolated Texas grid for graft and corruption, is not a legitimate reason to avoid buying electric vehicles. Itâ(TM)s a reason to investigate. Stop electing them and watch modern infrastructure get built that benefits everyone, just like every other modern economy, instead of state funds funneled to the well-connected in a sham public-private partnership. Fortunately most EVs arenâ(TM)t charging during maximum AC demand in the afternoons.

It makes no sense to complain of a poor record of development for an agency that routinely has massive arbitrary budget cuts and priority redirection. If someone cut your budget by half every four to eight years, and rearranged your long-term tasks, you would have less productivity, too.

When Ellsberg leaked the Pentagon papers, and the NYT had the stones to publish articles about them, it showed that the US Government had been lying to Americans for decades about Vietnam. It showed that the Pentagon didnâ(TM)t think we could win the Vietnam War - at least not within the parameters it was permitted by the Executive branch trying to avoid nuclear war with China, which stood in stark opposition to public press releases expressing confidence in American victory over communism in Vietnam. The Pentagon Papers showed that tens of thousands of Americans had died fighting an un-winable war for political reasons. No President had wanted to take responsibility for loosing, and admit to the American people that there were limits to what they could achieve in the Cold War. Thatâ(TM)s why journalists since have been cautious and critical of official government accounts, and time and again, their skepticism has been rewarded. See also Bush administration claims, re: Iraqi WMDs c. 2003.

Should say, ^hope the AI can pick up SVC syndrome.

Itâ(TM)s probably a statement that comes from the experience that women have with breast radiologists, who also biopsy the lesions they find, discuss really difficult diagnoses & options, and may come to care for them longitudinally. Many radiologists perform image guided procedures, but breast radiologists typically have the most regular, ongoing care of women in breast cancer screening and cancer treatment. That being said, your local hospital would grind to a halt without image guided biopsy, drains, line placement, and therapy performed by both interventional and diagnostic radiologists. Robots arenâ(TM)t here for that yet, even if an AI can pick up a lesion on a study without too much motion or artifact. Hope the IR can also reliably catch SVC syndrome on the mammogram, because you need to look for other problems beyond cancer on any imaging study.

The whole world needs better oligarchs, and for Musk in particular to focus on his societal improvement businesses and not giving aid and comfort to fascists. Unfortunately for all of us, if Musk read Marcus Aurelius he certainly didnâ(TM)t take him to heart, with glimpses of Caligula slipping through.

If the did FBI undermine Trump and help Biden, it would have been doing their jobs since Trump was & is a full-on Russian asset that a third of the country was too dumb to see - blinded by admiration of his racism.

Thereâ(TM)s a big difference between a few people sending encrypted files with a cumbersome workflow and imperfect operational security, and all of gmail being encrypted. I would expect a back door in any large corporate encryption product, post 9/11.