Natural science has grown by tremendous leaps and bounds in the last 4-5 centuries. Applied science has also grown a lot, but our tools can only be fashioned so fast to keep up with the new resolutions, new resolutions of data and types of substances and materials that are being created or conceived of every day. We have so many technologies available to play with and rearrange, that we can engage in forms of meta-science - discovering anew every day how to use what we've created, never mind what nature has left lying around for us. While nature remains more creative and ingenious than us, it's easier to order stuff online and discover them in a living room than to organize a biosample collection safari and then analyze it using wetlabs, NMR, mass-spec, etc.
In some realms of science we're caught in a handful of high-expense, low-return endeavors at this point. Many avenues that are currently not in the spotlight are going to turn out to be the way of the future, but we'll only know that after the fact.
Progress in biotech, nanotech, robotics, computing, neuroscience, genetics, energy storage, photovoltaics, networks, complex systems, pharmaceuticals, semiconductors, (and several more I'm forgetting for sure) is proceeding like crazy, and prices for all these things are plummeting. When enough plummeting has happened, the basic tools of science and industry will have completely changed in character, and then new waves become possible. There is so much progress it is time-consuming for us to get to grips with it.
Or is it possible that we're nearing the edge of what's possible for human minds to comprehend, and the next steps will involve having AI do the discovery-making, and one of the challenges will be knowing how to get the AI to tell us what it knows in terms we can handle?
This whole discussion reminds me of that Richard Feynman quote about quantum mechanics: (to paraphrase -) we've learned the rules of chess, but how many years before we master the game?
As far as I'm concerned, the reason we're not finding 'new laws' of nature is partly because we've already found so many, and possibly they are finite after all, but also we've created such a vast inner (artificial) kingdom of knowledge that you can live your whole life within it without peaking outside - you can discover what humans have created for lifetimes and lifetimes and never find the end. And then there is Youtube. egad.