rahultyagi writes: "River blindness" and Onchocerciasis are diseases of tropical countries in Africa and South America that are caused by the tiny roundworm O. volvulus. Millions of people in these countries carry this worm, with some of the symptoms being devastating impact on quality of life, health and economy in these poor and developing countries. Large scale drug administration has shown promise over last few decades but new drugs are always in demand because of possibility of development of drug resistance. Two new papers in "Nature Microbiology" describe the genome sequence and the genomic diversity that existed before current drugs modified the genomic landscape. This data will hopefully accelerate the demise of this terrible affliction.