Exactly what I was going to say. My fiancee is terrible at dexterous video games, but loves point and clicks.
Granted, she grew up playing them, so she's got a little more interest than your wife might.
But this way you have two options:
A.) You can now play your video games, guilt free, right next to her while she plays hers.
B.) If she's stuck or if you like point and clicks as well or for whatever reason you can sit there with her and play it together by figuring out the puzzles, talk about where to go next, etc.
Games we've done like this are the Nancy Drew games and Monkey Island games.
Also, Sims works and she even got into KotOR, since movement isn't imperative and you can pause combat as much as you'd like. It helps that she's already a big RPer and SW nerd though, so a lot of it will just depend on your wife's interests.
Another alternative, which I'm sure people have mentioned are some Kinect or Wii games, like Wii Sports, Mario Cart, etc.