It's well known that the resistance genes come at a cost. As soon as they stop being important, they start giving way to other things the cell needs more. It's great to see phage treatment making inroads here in the west, but if we could stop hammer our own thumbs with antibiotics that would be an excellent start.

Using an LLM is like walking a husky - which is to say the husky walks you, mostly.

I had problems like this, went through an evolutionary process, finally ended with building an app to enter data, because endless token burning for a simple task. The LLM got red only access via Postgres, and it chafed for weeks when it discovered it was no longer able to edit anything.

LLMs can do cool stuff, looks like my startup is gonna get to $2m - $3m in series A funding, but constraining bad impulses is still a quarter of my work.