Submission + - SPAM: New Class of Drug Reverses Paralysis In Mice
An anonymous reader writes: US scientists have developed a new form of drug that promotes the regeneration of cells and reversed paralysis in mice with spinal injuries, allowing them to walk again within four weeks of treatment. The research was published in the journal Science on Thursday, and the team of Northwestern University scientists behind it hope to approach the Food and Drug Administration as early as next year to propose human trials. [Northwestern's Samuel Stupp, who led the study, and his team] used nanofibers to mimic the architecture of the "extracellular matrix" — a naturally occurring network of molecules surrounding tissue that is responsible for supporting cells. Each fiber is about 10,000 times narrower than a human hair, and they are made up of hundreds of thousands of bioactive molecules called peptides that transmit signals to promote nerve regeneration. The therapy was injected as a gel into tissue surrounding the spinal cords of lab mice 24 hours after an incision was made in their spines.
The team decided to wait a day because humans who receive devastating spinal injuries from car accidents, gunshots and so on also experience delays in getting treatment. Four weeks later, mice who received the treatment regained their ability to walk almost as well as before the injury. Those left untreated did not. The mice were then put down to examine the impacts of the therapy on the cellular level, and the team found dramatic improvements to the spinal cords. The severed extensions of neurons called axons regenerated, and scar tissue that can act as a physical barrier to regeneration was significantly diminished. What's more, an insulating layer of axons called myelin that is important in transmitting electric signals had reformed, blood vessels that deliver nutrients to injured cells had formed, and more motor neurons survived.
A key discovery by the team was that creating a certain mutation in the molecules intensified their collective motion and heightened their efficacy. This is because receptors in neurons are naturally in constant motion, Stupp explained, and increasing the motion of the therapeutic molecules within the nanofibers helps connect them more effectively with their moving targets. The researchers in fact tested two versions of the treatment — one with the mutation and one without — and found that mice that received the modified version regained more function. The gel developed by the scientists is the first of its kind, but could usher in a new generation of medicines known as "supramolecular drugs," because the therapy is an assembly of many molecules rather than a single molecule, said Stupp. According to the team, it is safe because the materials biodegrade within a matter of weeks and become nutrients for cells. Stupp said he hopes to rapidly move direct to human studies next without the need for further animal testing, such as on primates.
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The team decided to wait a day because humans who receive devastating spinal injuries from car accidents, gunshots and so on also experience delays in getting treatment. Four weeks later, mice who received the treatment regained their ability to walk almost as well as before the injury. Those left untreated did not. The mice were then put down to examine the impacts of the therapy on the cellular level, and the team found dramatic improvements to the spinal cords. The severed extensions of neurons called axons regenerated, and scar tissue that can act as a physical barrier to regeneration was significantly diminished. What's more, an insulating layer of axons called myelin that is important in transmitting electric signals had reformed, blood vessels that deliver nutrients to injured cells had formed, and more motor neurons survived.
A key discovery by the team was that creating a certain mutation in the molecules intensified their collective motion and heightened their efficacy. This is because receptors in neurons are naturally in constant motion, Stupp explained, and increasing the motion of the therapeutic molecules within the nanofibers helps connect them more effectively with their moving targets. The researchers in fact tested two versions of the treatment — one with the mutation and one without — and found that mice that received the modified version regained more function. The gel developed by the scientists is the first of its kind, but could usher in a new generation of medicines known as "supramolecular drugs," because the therapy is an assembly of many molecules rather than a single molecule, said Stupp. According to the team, it is safe because the materials biodegrade within a matter of weeks and become nutrients for cells. Stupp said he hopes to rapidly move direct to human studies next without the need for further animal testing, such as on primates.
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