Scientists have created a flock of sheep that carry the gene for a lethal inherited brain disorder in humans. The condition, Batten disease, usually starts in childhood and is invariably fatal, often within a few years of diagnosis. From a report: The project, which is designed to test treatments for the disease, is based at Edinburgh University's Roslin Institute, where cloning techniques were used to create Dolly the sheep in 1996. The scientists acknowledge that the approach could be controversial as it involves creating animals programmed to die, but stress that their aim is to alleviate human suffering. "We have deliberately re-created the condition in a large mammal because sheep have a brain of a similar size and complexity to that of a child," said Tom Wishart, project leader. "That means treatments we test on them are much more likely to be relevant to humans than those tested only on cell cultures or mice and rats."

In the UK, Batten disease affects between 100 and 150 children and young adults. It is inherited from two symptomless parents who each carry a rare recessive gene mutation. That mutation interferes with the operation of lysosomes, which act as the waste disposal systems for cells. Children who carry two copies of the faulty gene begin to suffer loss of vision, impaired cognition and mobility problems. Seizures and early death follow. "It is devastating for families," Wishart said. There are several types of Batten disease, he added. "One of the more rapid types is CLN1, and that's what we have recreated in our sheep." The Roslin scientists used the gene-editing technique Crispr-Cas9 to create the faulty CLN1 gene in the sheep. "We collected sheep embryos from the abattoir," Wishart said. "Then we fertilised them and added Crispr reagents to alter their genetic structure before implanting the embryos into a surrogate sheep's uterus."

newviewmedia.com writes "Scientists at the Lawrence Livermore National Laboratory plan on using a laser the size of three football fields to set off a nuclear reaction so intense that it will make a star bloom on the surface of the Earth. If they're successful, the scientists hope to solve the global energy crisis by harnessing the energy generated by the mini-star."

mstansberry writes "Is IBM considering relaunching OS/2? One source close to IBM says Big Blue plans to repurpose OS/2 services atop a Linux core. IT managers ask, why now?" Hey, back in simpler times OS/2 was super badass. Both of the guys who ran it were hard core.

Hugh Pickens writes "The Washington Post reports that under Obama's new 'Nuclear Posture Review,' released today, the US will foreswear the use of the nuclear weapons against nonnuclear countries, in contrast to previous administrations, which indicated they might use nuclear arms against nonnuclear states in retaliation for a biological or chemical attack. But the new policy included a major caveat: The countries must be in compliance with their nonproliferation obligations under international treaties. The problem for Iran and North Korea is that the pledge does not cover them because the US regards them as in non-compliance with the Non-Proliferation Treaty. The new policy will also describe the purpose of US weapons as being fundamentally for deterrence. Some Democratic legislators had urged Obama to go further and declare that the United States would not use nuclear weapons first in a conflict, but officials worried that such a change could unnerve allies protected by the US nuclear 'umbrella.' The president of the Ploughshares Fund said of the new stance, 'It orients US policy towards dramatically fewer weapons and greatly reduced roles.'"

Time Doctor writes "There has been a lot of information going around about Nexuiz, the GPL, and what the Nexuiz leadership has done. A new interview has gone up with DarkPlaces developer Forest Hale to set things straight. Quoting: 'The original plan was to contact every developer and relicense the Nexuiz 2.5.2 GPL gamecode sources for this title, to ensure authentic gameplay and return some important features to the community for the benefit of everyone. However this gamecode re-licensing attempt did not go well; with the former developers making claims of violations there was no choice but to re-implement the gamecode from scratch on non-GPL sources. As a result there will be no ongoing code contributions back to the community, and the gameplay may differ more than originally planned. This is a very unfortunate outcome but has no significant impact on development. To make this perfectly clear – the game is being reimplemented from scratch; all they share is a name.'"

taucross writes "A new site allows lonely Xbox 360 gamers to pay a prescribed fee for a few minutes of game time with one of the 'PlayDates', a girl who is paid to play video games. Gamers can choose to have a 'flirty' or 'dirty' experience with one of the PlayDates. Is this what we meant when we said we wanted 'adult gaming'?"

Kohato brings word of a new Electronic Arts marketing strategy that aims to start monetizing game demos. According to industry analyst Michael Patcher after an EA investor visit, the publisher will start selling "premium downloadable content" prior to a game's release for $10-$15 that is essentially a longer-than-usual demo. Patcher said, "I think that the plan is to release PDLC at $15 that has 3-4 hours of gameplay, so [it has] a very high perceived value, then [EA will] take the feedback from the community (press and players) to tweak the follow-on full game that will be released at a normal packaged price point." He also made reference to a comment from EA's CEO John Riccitiello that "the line between packaged product sales and digital revenues would soon begin to blur."

abs0lutz3ro writes with a major update to the Google/China situation we've been discussing so much lately: "Google has stopped censoring simplified Chinese search results on google.cn by redirecting users to google.com.hk, which Google maintains is entirely legal. From the official blog: 'We want as many people in the world as possible to have access to our services, including users in mainland China, yet the Chinese government has been crystal clear throughout our discussions that self-censorship is a non-negotiable legal requirement. We believe this new approach of providing uncensored search in simplified Chinese from Google.com.hk is a sensible solution to the challenges we've faced—it's entirely legal and will meaningfully increase access to information for people in China. We very much hope that the Chinese government respects our decision, though we are well aware that it could at any time block access to our services. We will therefore be carefully monitoring access issues, and have created this new web page, which we will update regularly each day, so that everyone can see which Google services are available in China.' Seems like google.cn got served (from google.com.hk)."

An anonymous reader writes "Chris Jarvis, 31, is described as a Star Wars fan and member of the International Church of Jediism. Said church's intergalactic hoodie uniform is at odds with the strict doctrine of the Department for Work and Pensions, which may require Jobcentre 'customers' to remove crash helmets or hoods for 'security reasons.' Following his ejection, Jarvis filled out a complaint form and within three days got a written apology from branch boss Wendy Flewers. She said: 'We are committed to provide a customer service which embraces diversity and respects customers' religion.'"

An anonymous reader writes "Michael Seringhaus, a Yale Law School student, writes in the NY Times, 'To Stop Crime, Share Your Genes.' In order to prevent discrimination when it comes to collecting DNA samples from criminals (and even people who are simply arrested), he proposes that the government collect a DNA profile from everybody, perhaps at birth (yes, you heard that right)." Regarding the obvious issue of genetic privacy, Seringhaus makes this argument: "Your sensitive genetic information would be safe. A DNA profile distills a person’s complex genomic information down to a set of 26 numerical values, each characterizing the length of a certain repeated sequence of 'junk' DNA that differs from person to person. Although these genetic differences are biologically meaningless — they don’t correlate with any observable characteristics — tabulating the number of repeats creates a unique identifier, a DNA 'fingerprint.' The genetic privacy risk from such profiling is virtually nil, because these records include none of the health and biological data present in one’s genome as a whole."

smooth wombat writes "Before the advent of iTunes and MP3s, EMI and Pink Floyd entered into a contract which stated that EMI could not unbundle individual songs from their original album settings. This was insisted upon by the members of Pink Floyd, who wanted to retain artistic control of their works, which they considered 'seamless' pieces of music. However, with the advent of digital downloads, EMI has been selling individual songs through its online store. Pink Floyd sued, claiming EMI was violating the contract, whereas EMI said the contract only applied to physical albums, not Internet sales. Judge Andrew Morritt backed the band, saying the contract protected 'the artistic integrity of the albums.' Judge Morritt also ruled EMI is 'not entitled to exploit recordings by online distribution or by any other means other than the complete original album without Pink Floyd's consent.'"