I currently work with mass spectrometry to study differences in protein expression levels to understand cancer. By using the Orbitrap, we are able to study proteins in femtomolar levels and we are still far from detecting biomarkers. In deed, the field of proteomics recognizes that such is still an open chalenge, even when analyzing simple cell cultures instead of complex biofluids such as plasma. The field has become tired of published manuscripts of biomarkers that have proven wrong and are an artifact of overfiting statistical approaches. In this regard, it could be misleading to "advertise" and article as such before proving the claims on large populations.