Perhaps it's time to do away with phrases like "browser will replace the desktop" and "browser-based OS", because they seem to bring about angry friction in old-school developers.
I tend to think that "desktop" operating systems and their BIOS's will eventually merge to provide a base hardware interface whereas the browser becomes a base for most software. And I say most, but realistically everything is on or going to the web and to say otherwise is a denial. It's been nearly 15 years since I started using the internet and all I've seen is a inexorable shift from OS-specific to browser-based. Sure there's obstacles related to privacy, technology, and people but it's only delays (the singularity is near?).
All that said, I prefer Chrome as my primary perusal platform. It generally stays out of my way and handles things as I expect. Whether or not Google has its eye on a permanent place amongst similar products, its speedy minimalist approach is a sexy suggestion to its peers.