I took online classes in DeVry University/Keller Management School last year, and used only my home Linux computer for that.
Apart from a project management class that required MS Project (demo-version works under Wine), all was fine until the final class, where prof strongly insisted on everyone using only Office 2007 docx/pptx files for everything. At the same time Devry administration issued a letter that whole university migrates to Office 2007, and everyone should have it. It was very disappointing decision.