I've been using Comodo Anti-virus (http://antivirus.comodo.com/) for a while now. Started with their firewall a while ago and then they bundled the AV. Good timing because AVG was bloating out at the time. I've had good experiences with this and most of my siblings now use it to and I pretty much get no support calls now. I don't use the Defence+ thing most of the time though.

It's all well and good predicting the outcomes. In general the consensus says it's not going to be pretty yet we still have no real action on preventing any of this.