One thing that I see from the Cable companies, phone companies and media companies is that they all try to regularly increase prices. If you're going to charge $7, $8, $9, just leave it there. Who wants to have to deal with price increases? I only subscribe to a streamer on Twitch and I might drop that. Service can decline as well. This morning I looked at a bottle of Gatorade which I thought was 1-Liter. It turns out that it's 28 ounces. Package shrinkage is another form of inflation. There is no inflation, prices shouldn't be going up.

Always better to read the actual research paper. You might also have a cancer cell that's fixed by the Mismatch Repair mechanism. Do this report cancer in the case where cells can be repaired?

Some cancers have markers on the cell surface and immunotherapy exploits these markers to go after just cancer cells. But some mutations like KRAS, NRAS, HRAS, the so-called undruggables, don't have markers on the cell surface that we currently know of. There has been some remarkable work at NCI, particularly with KRAS G12D and KRAS G12V, that present markers on the cell surface with certain alleles and this has led to a few immunotherapy cures. But this stuff is in its infancy. There are some 39 or so cancers and hundreds of gene mutations. Does this test cover all of those? I would be skeptical that it covers everything.

DNA in solid tumors may not migrate into the bloodstream (you actually don't want this as this is how cancer spreads).

My last three care were Toyotas. The first I traded in with 250K miles - it still ran fine. The other two I still have, one with 100K and the other with 8K. I've taken the factory tour and there were a lot of US employees working seemingly happily there. I would be happy to buy a Ford or GM if they were as reliable as the Toyotas are.

I'm sadistic - I like assembler.

Housing values at the high-end are already suffering in some cities and I'd agree that higher interest rates will help. There are lots of places where property isn't expensive but they aren't hubs. Many could live there - the folks that can work remotely - if broadband is good.

I wasn't able to exercise much for over a year though I walked 900 miles this summer. The problem with this kind of exercise was the lack of intensity (I ran, lifted and played tennis before being forced to take time off). I had a cardiac event which was caused by dehydration and saw a cardiologist and he suggested some intensity. I bought a Fenix 5+ and it showed that my while driving or working between 80 and 100. A few weeks of running got it down between 70-80. The running dropped my stress scores as well. The health tracking tech is really great stuff for looking at metrics which affect heart health, stress, sleep, etc.

There's the VAT in Canada. We have a lot of Canadian shoppers coming down to our malls in my state. Had a ton of them vacationing here too.

The rumors come out every year. I have my eye on the 32 GB Core i9 MacBook Pro. Where's the ARM equivalent? Can it run Solaris, Linux, Windows? The margins have to be great for the 8th gen i7 and i9 models.

I upgraded to 11.4 a while ago and didn't see any problems. What I usually see is articles saying that battery life is better for some and worse for others. I'd guess that it's App issues.

Yup. The people that run companies don't want their own offices to be open either.

Best bang for your buck depends on what you do. My total bill last month was $7.44 for four phones or less than $2/phone/month and this on Verizon's network.

Both are deal-killers for me. I have a 2014 MBP and it's fine but Apple would have to fix these two issues for me to upgrade. I just bought a 1 TB SSD and 4 GB of RAM to add to an old 17 inch 2008 MBP - better keyboard than everything that has come after. I usually hook up a mechanical keyboard with Cherry MX Blues to my systems and only use the built-in keyboard when I'm at a coffee shop or otherwise mobile. So Apple: 1) fix the keyboards, 2) fix the video, 3) update the Mini, 4) Update the Pro. Give a little love to your Macs.

Do they have a recovery plan?