Perhaps more of a trade-off than an all-out win? (Score 1)

As a 43-year-old male who has had a matched unrelated donor transplant (MUD) for acute mylogenous leukemia (AML, subtype M6) at age 35, I can tell you that having total body irradiation (TBI) and ablative chemotherapy is no walk in the park, and my chances of acquiring seconary cancers later in life is dramatically increased. So, for those requiring solid organ transplant, this approach is perhaps a win relative to the toxicity and other effects of lifelong immuneosuppression, I suspect it is far from a panacea. In addition, I think its worth noting that these findings were NOT based on fully-ablative bone marrow transplantation, as chimerism resulted (and indeed, was sought). Thus, the promise of no chronic graft-vs-host disease does NOT apply to those needing fully-ablative transplants (e.g., leukemias and other blood-based cancers or disorders requiring complete destruction of the host bone marrow).