Having cut my teeth on Red Hat and Mandrake over a decade ago, I'm not a Linux newbie. That said, I don't tend to compile kernels or, these days, build much software from source. Earlier Ubuntus, with their Gnome 2, became my workstation operating system of choice. I stopped tinkering with the OS internals because productivity was more important and *things* *just* *worked* - until Unity.
I still liked Ubuntu's lack of hassle and the Debian roots, but was disappointed with Unity (it might be OK for craptops and netbooks, but it's awful on dual monitor rigs...assuming it bothers to detect the second monitor.) The Unity workflow is broken and I felt that it was less of a work platform (i.e. somewhere where I could run the handful of apps I require.)
I installed Mint on my laptop and liked it. Then I read about LMDE and live-booted it on my workstation. I installed it right away - hassle free, runs my apps and disappears into the background (as all good operating systems should.) I update it when I need to and it has the reassuring Debian feel (but it's suitably different from Debian.) I don't know why I like the fact it's different from Debian, but I do.
Anyhow, dear readers, LMDE - I heartily recommend it to you. It's beautifully uncomplicated and a joy to use.