...Great comments, especially WRT the UBEC. My work is always in a lab environment (or at home, where I use beefy USB chargers...), so it never occurred to me to look toward the RC world for an inexpensive DC-DC converter. Thank you for that!
The RPi is not designed for industrial application, and every one of the characteristics you cite, while being important for "pro-grade" product performance, also add cost that is unnecessary for 99.9% of Pi use-cases. Professional engineering time (that's us...) is precious, so we don't screw around with toys for delivered production hardware. The RPi, Odroids, Pines, Pi-clones, even the Beaglebone Black are all fabulous toys that we use to support diagnostics, lab automation, etc: If a $4.99 SD croaks we image a new one and we're back in business.
Industrial strength hardware (fanless industrial PC) costs about 20x the toy hardware: about 700-1000US but it's still fabulously cheap compared to the way it used to be. (I won't get into the ugly details of trying to talk my management into getting rid of VME hardware and 25 year old designs...)
Especially when combined with trick like RAM-resident root and tmp filesystems, EXT3/EXT4 on modern high-endurance flash is fine, as far as I can tell. I've run endurance checks of our current CF cards (1 or 2 gig, extended-endurance) and they are still just fine after 10-15 years of simulated activity. Our product uses flash only for logging and vehicle reporting. Modern wear-leveling and larger media let us forget the whole endurance question. NO more JFFS2!