I've just started playing. So far, I've been using bootcamp. I posted a link to a Linux/OS X launcher in a previous reply. That (https://launchpad.net/pylotro) plus Crossover appears to be working for some. Instructions at http://forums.ddo.com/showthread.php?t=200985.
Linux/OS X launcher:
"...a most excellent barbarian ... Genghis Kahn!" -- _Bill And Ted's Excellent Adventure_