Comment Targus Sport Deluxe Backpack (Score 1) 824
After deciding that my Apachecon-Europe totebag really wasn't suitable for lugging my Vaio around any longer (due to a complete lack of padding, and the fact that there wasn't enough room to carry my glasses around in it as well), I spent a while looking and turned up the Targus Sport Deluxe Backpack, which I got from ThinkGeek because Targus inexplicably refuse to sell it in the UK...
It's enormous, but as long as you don't mind that, it's great. Enough room to carry books, folders, lunch, etc. in a separate compartment to the laptop. Plenty of pockets for accesories, cables (and my fsck'ing glasses). And I have no worries about the straps going.