ananyo writes "By analysing the chemical structure of a drug, researchers can see if it is likely to bind to, or 'dock' with, a biological target such as a protein. Researchers have now unveiled a computational effort that used Google's supercomputers to assesses billions of potential dockings on the basis of drug and protein information held in public databases. The effort will help researchers to find potentially toxic side effects and to predict how and where a compound might work in the body. 'It's the largest computational docking ever done by mankind,' says Timothy Cardozo, a pharmacologist at New York University's Langone Medical Center, who presented the project at the US National Institutes of Health's High Risk–High Reward Symposium in Bethesda, Maryland. The result, a website called Drugable, is still in testing, but it will eventually be available for free, allowing researchers to predict how and where a compound might work in the body, purely on the basis of chemical structure."

alphadogg writes "Just as Internet users in general have defected in huge numbers from Microsoft Internet Explorer over the past several years, the business world, as well, is becoming less dependent on the venerable browser. Companies that used to mandate the use of IE for access to web resources are beginning to embrace a far more heterodox attitude toward web browsers. While it hasn't gone away, the experience of having to use IE 6 to access some legacy in-house web app is becoming less common. 'A lot of it has to do with the emergence of the modern web and the popularity of mobile. They have made it very different for companies to truly standardize on a browser,' says Gartner Research analyst David Mitchell Smith."

MrSeb writes "Engineers at Caltech and the University of Victoria in Canada have smashed their own internet speed records, achieving a memory-to-memory transfer rate of 339 gigabits per second (53GB/s), 187Gbps (29GB/s) over a single duplex 100-gigabit connection, and a max disk-to-disk transfer speed of 96Gbps (15GB/s). At a sustained rate of 339Gbps, such a network could transfer four million gigabytes (4PB) of data per day — or around 200,000 Blu-ray movie rips. These speed records are all very impressive, but what's the point? Put simply, the scientific world deals with vasts amount of data — and that data needs to be moved around the world quickly. The most obvious example of this is CERN's Large Hadron Collider; in the past year, the high-speed academic networks connecting CERN to the outside world have transferred more than 100 petabytes of data. It is because of these networks that we can discover new particles, such as the Higgs boson. In essence, Caltech and the University of Victoria have taken it upon themselves to ride the bleeding edge of high-speed networks so that science can continue to prosper."

sciencehabit writes "Men typically produce working sperm as long as they live, but most textbooks say female mammals are born with all the egg cells, or oocytes, they will ever have. Since 2004, however, reproductive biologist Jonathan Tilly of Massachusetts General Hospital in Boston has challenged that conventional wisdom, arguing that in mice—and perhaps also in humans—there must be an ongoing source of new eggs. Today, Tilly and his colleagues report isolating rare cells in ovarian tissue from adult women that can grow in lab dishes and form immature oocytes. The potential egg stem cells could help scientists devise new ways to help rescue the fertility of women who have to undergo cancer treatments or who suffer from premature menopause."

alphadogg writes "Patent litigation between Motorola and Research In Motion is heating up, with Motorola filing a complaint with the US International Trade Commission. In the complaint, Motorola alleges that RIM engages in unfair trade practices by importing and selling products that infringe five Motorola patents. The patents cover technologies related to Wi-Fi access, application management, user interface, and power management, Motorola said. Motorola is asking the ITC to investigate RIM and bar the company from importing, marketing, and selling products in the US that use the technologies."

krou writes "According the Guardian, some 30 million chip and pin cards in Germany have been affected by a programming failure, which saw the microchips in cards unable to recognize the year change. The bug has left millions of credit and debit card users unable to withdraw money or make purchases, and has stranded many on holiday. French card manufacturer Gemalto accepted responsibility for the fault, 'which it is estimated will cost €300m (£270m) to rectify.' They claim cards in other countries made by Gemalto are unaffected."

davecl writes "ESA's Herschel Space Telescope has released its first spectroscopic results. These include observations of VYCMa, a star 50 times as massive as the sun and soon to become a supernova, as well as a nearby galaxy, more distant colliding starburst galaxies and a comet in our own solar system. The spectra show more lines than have ever been seen in these objects in the far-infrared and will allow astronomers to work out the detailed chemistry and physics behind star and planet formation as well as the last stages of stellar evolution before VYCMa's eventual collapse into a supernova. More coverage is available at the Herschel Mission Blog, which I run."

KingofGnG writes "DOSBox, the emulator designed to run DOS games on modern operating systems (and not necessarily on a PC), has been chosen as project of the month for May on SourceForge. It's the latest award granted to a piece of software that 'simply does what it is supposed to do,' as the authors say. After having amassed more than 10 million downloads, it will soon be getting an update that's been awaited for almost two years."

The recently released Grand Theft Auto: Chinatown Wars is one of only a handful of mature-rated titles for the Nintendo DS, so the industry is watching closely to see if the traditionally family-friendly market can support such titles. While sales have not been stellar, they haven't been terrible either, easily outperforming previous M-rated titles. If they continue to improve, it's possible we'll start seeing a more consistent effort for "serious" games on Nintendo's portable console. "In the end, Singer said Nintendo hopes that the sales story of Grand Theft Auto: Chinatown Wars will be an encouraging one for game publishers. 'I think strategically, this is a very important game because it helps send the message that great M-rated content can come to the platform and will find a home.'"