Google has announced a "developer preview" of a new search infrastructure, though one wouldn't have to be a developer to try it out. Google is asking for feedback on how the search results in the new regime stack up against the old. Matt Cutts has posted a mini FAQ. Some early testing indicates that the new search may be faster in some cases, and return more relevant results, than the old one. Those who attempt to game Google search for a living will be scrambling henceforth. Has anyone identified the new crawler bot in log files?

Linuss points out research published in PLoS Biology that demonstrates the reawakening of latent human cells' ability to manufacture an HIV defense. A group of scientists led by Nitya Venkataraman began with the knowledge that Old World monkeys have a built-in immunity to HIV: a protein that can prevent HIV from entering cell walls and starting an infection. They examined the human genome for any evidence of a latent gene that could manufacture such a protein, and found the capability in a stretch of what has been dismissively termed "junk DNA." "In this work, we reveal that, upon correction of the premature termination codon in theta-defensin pseudogenes, human myeloid cells produce cyclic, antiviral peptides (which we have termed 'retrocyclins'), indicating that the cells retain the intact machinery to make cyclic peptides. Furthermore, we exploited the ability of aminoglycoside antibiotics to read-through the premature termination codon within retrocyclin transcripts to produce functional peptides that are active against HIV-1. Given that the endogenous production of retrocyclins could also be restored in human cervicovaginal tissues, we propose that aminoglycoside-based topical microbicides might be useful in preventing sexual transmission of HIV-1."

mightysquirrel writes "It's been a year since Bill Gates left Microsoft in his official capacity. At the time many speculated his departure would spark a significant shift in Redmond. But how much has really changed during Microsoft's first year without Gates?"

narramissic writes "'Hundreds and hundreds of documents about government contracts,' were found on a hard drive purchased at a market in Ghana for the bargain basement price of $40, said Peter Klein, an associate professor with the University of British Columbia, who led an investigation into the global electronic waste business for the PBS show Frontline. The hard drive had belonged to US government contractor Northrop Grumman and in a made-for-TV ironic twist, 'some of the documents talked about how to recruit airport screeners and several of them even covered data security practices,' Klein said. 'Here were these contracts being awarded based on their ability to keep the data safe.'"

Hugh Pickens writes "Troy Wolverton writes in the Mercury News that in less than a year, the iPhone has become a significant game platform, but its bigger impact could be to help change the way the game industry does business. 'It's got everything you need to be a game changer,' said Neil Young, co-founder and CEO of ngmoco, which develops games solely for the iPhone. With a year under its belt and an installed base of iPhone and iPod Touch owners at around forty million, the iPhone/iPod Touch platform has eclipsed next-gen console penetration numbers and started to catch up to the worldwide penetration of both Sony's (50 million) and Nintendo's (100 million) devices. Wolverton writes that not only is the iPhone one of the first widely successful gaming platforms in which games are completely digitally distributed, but on the iPhone, consumers can find more games updated more often, and at a cheaper cost per game than what they'd find on a typical dedicated game console. While an ordinary top-of-the-line game for Microsoft's Xbox 360 sells for about $60, and one for Nintendo's DS about $30, a top-of-the-line iPhone game typically sells for no more than $10. With traditional games, developers might wait a year or two between major releases; ngmoco is planning on releasing new versions of its games for the iPhone every four to five months. 'You have to think differently,' says Young. 'It's redefining what it means to be a publisher in this world.'"

Tim Anderson writes "Microsoft's Scott Guthrie, Corporate VP of the .NET developer division, announced that the open source jQuery Javascript library will be integrated into Visual Studio, the main Windows development tool. Further, Microsoft will treat jQuery as a supported product within technical support contracts, and will use jQuery to build new controls for ASP.NET, its web platform."