I have a a Yamaha Aventage AVR, Anthem MCA 325 power amp and Dynaudio DM3/7 speakers, some pretty high end audio kit and it's in an acoustically treated room, and I don't think this would be worth it. I can sometimes notice a very subtle difference between a 320k mp3 and flac, but only if the recording is very good, and a recording that good is very rare today. For the few artists that I really enjoy who actually record and master their music well I'd just buy the CD.