My husband almost never gets sick, but when he does, it's rarely a minor illness. A little over two weeks ago, he came down with a very severe, very rapidly-progressing respiratory infection. Within a period of 96 hours, it went from a mild cough with no fever to severe pneumonia and a fever over 40C. The doctor prescribed amoxicillin/clavulanic acid on the morning of the third day, but it didn't really have any effect. My husband only started to get better once the doctor put him on levofloxacin a couple of days later. I think there's a very good chance his infection was caused by some kind of drug-resistant bacteria, but they didn't do any cultures, so we'll never know for sure.
On the other hand, I seem to be getting fewer and milder respiratory infections in the past few years. Even though I've always been prone to respiratory infections (I used to get bronchitis and/or pneumonia pretty much every winter), and have become quite a connoisseur of antibiotics, the worst I came down with this time was a mild ear/sinus infection and extreme fatigue. I also managed to avoid catching the H1N1 flu despite staying home to care for my daughter while she had it in 2009.
Reality must take precedence over public relations, for Mother Nature cannot be fooled. -- R.P. Feynman