The Hyperion technology is a lot safer than the low-level research and medical reactors that still quietly exist all over the planet - there is no liquid cooling system that can catastrophically fail and burial will secure the installations. Nimby alarmists ignore that nuclear power is the safest source of energy by any measure, once all the real risks are compared. Disposal is safe, but has been made too costly due to post TMI/Chernobyl hysteria.
Sadly, the worlds uranium supply is limited. And, even at current consumption levels, is likely to become very scarce within the next 50 years, or so. Another problem is scalability - how many of these plants will have to roll off the production line to provide even 10% of the world's base load? My quick calculation says about 50,000 will be needed to reach this target. That's a lot of systems and a lot of uranium.
If you want to be safe, stay out of the street, stay off the road, stay out of the sun, avoid food and drink.