Re:It's all about the measuring stick (Score 1)

Medieval European villages were never wiped out by cholera; the disease only arrived in Europe in 1817. Cholera had been in India a long time, but needed faster transportation to break out into Europe. Your typical CF mutation, especially delta508, is much much older than that. On the other hand, CFTR mutations mess up the particular channel used by s. Typhi: also, typhoid has been around a long time, could be dangerous even at low population density because about 2% of those infected become longtime carriers like Typhoid Mary (through a persistent infection of the gallbladder)