Comment What Kind of Database (Score 1, Interesting) 37
If you're talking about books, slides, and other physical items, then you need an OPAC or something like it. Delicious Library was suggested, but I'd guess that it wouldn't scale to meet your needs. Koha looks like a better bet. I haven't tried it out yet, but it definitely looks promising. I've been surprised that there isn't a major open source OPAC/ILS, since there are a lot of libraries doing a lot of software development, while at the same time paying ridiculous yearly licensing fees to the commercial ILS vendors.
If you're talking about managing digital images, movies, ebooks, websites, and other digital resources, then DSpace and Fedora are the two major players -- both are open source, and both seem to have a good number of users (though DSpace has the edge on that point). There's also NCState's MyLibrary, which is more of a portal system, for cataloging websites in addition to other types of resources. That could be useful for having a decent library website without having to do a lot of custom coding and database setup.
-e