If I take what you're stating correctly, then Article 10 would also be able to shoot down Medicare, Fannie/Freddie, the NEA, the DOL.... NASA.
In other words, it sounds right, but ever since the Civil War, I don't think it's been enforced in the manner you describe. There are specific exceptions in case law when dealing with commerce, and with health care spending in the top 5, it's a pretty easy out for the SC.
I think you need look no further than the DEA's position on medical marijuana laws to realize that the 10th isn't that powerful.
I'm not arguing that the 10th shouldn't be the law of the land, just that it plainly isn't, and a court challenge on strict 10th amendment grounds would cause an upheaval to the federal government.