Short answer: obesity is different from cancer
Long answer (anecdote): I was very obese since childhood till my mid thirties. I was 136 kg (NOT pounds) and i had multiple health issues like hypertension, hip pain, knee pain etc. i was working out for a long time as my dad was very strict on physical activities. I grew up in a very poor rural area in Asia and had never seen fast foods or processed food till I got a job and moved to a city.
My body raised several red flags and I was about to give up hope on living. Then I cut carbs to a great extent and included raw/whole foods like vegetables and nuts and boiled/baked meat on daily basis (meat is uncommon in my place and culture, like weakly once or twice). I lost more than 55kg and now in my ideal weight. People told me that it is my genetics, my body make-up etc. Doctors told me to cut down meat. But all turned out to be a lie. Meat (unprocessed and boiled/baked without much oil) and vegetables are the real food. My blood pressure is normal and I am healthier than ever.
Long answer (genral): No factor can break the first law of thermodynamics. If some gene or complex factor can create muscle or fat without food input, then we can create such animals and plants and solve world hunger. Free food forever! But no! That will never work. Empty calories like sugary drinks, hidden added sugar, fructose (even from fruits when consumed in excess) all these never fill our guts but add to the calories in our intake. So we consume more and more calories without feeling full. That was my problem too. I ate around 500g to 1kg of fruits and drank 1 litre of fruit juices with added sugar daily and wondered why I am fat despite eating "healthy fruits". Cut sugars and simple carbs. If there is a psychiatric or psychological issue to do this, get help. But don't say you can't beat obesity. It is easier to beat than you think