My company also struggled with an easy to use and robust offsite backup solution that backed up Windows servers with exchange along with our Linux and Unix servers running MySQL and other services. Backups were always a large headache for us and our customers. About two years ago we started testing multiple backup systems and running large scale recovery scenarios for our company and our customers. We needed it to be dead simple to use for both customers and administrators, offer revision control, encrypt the data, compress the data, and be able to store the data for up to 7 years or longer. In our quest to find and implement the ultimate solution we started our own company offering offsite backup, and we had over two years of testing and breaking many other solutions. Now we are the company our customers look towards to ease the stress of their backups both large and small.
http://datumguard.com/