Comment I'm surprised no one mentioned ColdFusion MX (Score 1) 801
Not only does CFML streamline many of your common tasks in middleware/front end processing, but the runtime deploys as a J2EE application on any J2EE-certified application server. This means that you can write all of your backend processing in Java and use those Java classes directly in ColdFusion.
I have experience with .Net, Java, and PHP and must say that you can get much more done much faster with ColdFusion.