In an attempt to control the mosquito-borne diseases yellow fever, dengue, chikungunya, and Zika fevers, a strain of transgenically modified Aedes aegypti mosquitoes containing a dominant lethal gene has been developed by a commercial company, Oxitec Ltd. If lethality is complete, releasing this strain should only reduce population size and not affect the genetics of the target populations. Approximately 450 thousand males of this strain were released each week for 27 months in Jacobina, Bahia, Brazil. We genotyped the release strain and the target Jacobina population before releases began for >21,000 single nucleotide polymorphisms (SNPs). Genetic sampling from the target population six, 12, and 27–30 months after releases commenced provides clear evidence that portions of the transgenic strain genome have been incorporated into the target population. Evidently, rare viable hybrid offspring between the release strain and the Jacobina population are sufficiently robust to be able to reproduce in nature. The release strain was developed using a strain originally from Cuba, then outcrossed to a Mexican population. Thus, Jacobina Ae. aegypti are now a mix of three populations. It is unclear how this may affect disease transmission or affect other efforts to control these dangerous vectors. These results highlight the importance of having in place a genetic monitoring program during such releases to detect un-anticipated outcomes.

A dose of hypocrisy is perhaps inevitable in an organisation the size of Microsoft. Critics level a more fundamental charge against its foreign policy, however. Where, they ask, does itâ"and fellow tech giantsâ"derive the legitimacy to be independent actors on the international stage? This is the wrong question to pose. As businesses, they have every right to defend the interests of shareholders, employees and customers. As global ones, their priorities may differ from those of their home countryâ(TM)s elected officials. And as entities which control much of the worldâ(TM)s digital infrastructure, they should have a say in designing the international norms which govern it. At a time when many governments refuse to lead, why should the firms not be allowed to? Especially if, like Microsoftâ(TM)s, their efforts blend principles with pragmatism.