Comment Debian = a lot of work (Score 1) 264
If you have experience with a particular distribution, go with that.
I set up a 512 core cluster using Debian about five years ago. If you go that route, I suggest using FAI for installation. That way you can re-image your systems on reboot and easily keep things up-to-date and make config changes system-wide by just rebooting your nodes.
Many software packages both commercial and open source are RedHat focused. I had to create my own deb packages for many softwares. This trend is not as strong as it was before, but RedHat still dominates the software world. Take that into consideration and know what you're using it for.
As for building a RedHat cluster, I can't comment on that like all of the others who have never built one. I don't have enough experience to give any thoughts towards it.
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