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Comment reading much harder than stimulating (Score 2, Interesting) 92

I mostly love this article, but it kinda glosses over how much more difficult it is to read out information out optically than it is to stimulate neurons with light. When you stimulate neurons you just need any ole photon, doesn't matter how many times it bounced around, or where it came from.. which is good because the brain isn't so much transparent, its kinda a milky haze. However, when you want to record optically from them you have to make an image of the neurons (unless you want all the neurons signals to get mixed together) and so you care about where all the photons came from. In order to take really effective pictures in the brain you need a fancy two photon microscope, and although some people are playing around with making tiny ones that one could potentially carry around on ones head.. they aren't really going to every be practically chronic implants for anyone, for many reasons.. but first of all you need to hook them up to a large, expensive infrared laser to make it work. That's not to say all this optical reading isn't really awesome, because scientists can make use of it to learn things about brains in more constrained situations.. i just wouldn't look to it to be the missing link in brain machine interfaces anytime soon.
Science

Submission + - Scientists use Quake 2 to study the brains of mice (nature.com)

An anonymous reader writes: In this week's issue of Nature, scientists from Princeton University trained mice to navigate around in a virtual environment, using a setup that resembles a combination of a giant trackball and a mini-imax theater displaying a virtual world rendered using a modified version of the Quake 2 open source game engine. Holding the mouse's head still atop this giant trackball, the mouse can run on the ball and they use the rotations to move the mouse around in the virtual environment, and when he reaches certain places he gets a reward. Because they are able to hold the head still, they can stick microscopic glass electrodes into individual neurons in the hippocampus of this mouse as it "navigates". They find the neural activity that resembles activity during real life navigation, and learned new things about the inputs and computations that are going on inside these neurons which weren't known before.

No word as of yet whether the scientists plan on giving the mice control of the gun. Wonder whether John Carmack ever envisioned this when he opened up the Quake code?

nature article)
http://www.nature.com/nature/journal/v461/n7266/edsumm/e091015-01.html

wired has a story with video, though not of the mazed used in the paper
http://www.wired.com/wiredscience/2009/10/mouse-virtual-reality/
as does gizmodo) http://gizmodo.com/5381828/real-mouse-navigates-quake-2-using-a-trackball#comments
engadget) http://www.engadget.com/2009/10/15/mice-run-through-quake-princeton-neuroscientists-scan-their-bra/
switched)http://www.switched.com/2009/10/15/gaming-mice-help-scientists-study-brains/

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