Comment Many options (Score 1) 185
There are many OS projects in education, and many (schooltool, claroline, sakai, moodle, drupaled, edubuntu, etc) have been mentioned in this thread.
Tom Hoffman, the lead on the schooltool project, has had an open source SIF Zone Integration Server for over a year: http://www.tuttlesvc.org/2007/03/wye-zone-integra
Center SIS and the Miller Group ( the folks behind os4ed -- see http://www.miller-group.net/content/view/113/1/ ) had a dust up last year with one of the original developers. For details, see http://arcknowledge.com/law.gpl.violations.legal/
As a result of this issue, we also have Focus/SIS as another open source alternative: http://www.focus-sis.org/
So, we have a plethora of possible solutions -- what would be nice to see is some collaboration between these different groups, with clearly defined APIs and code examples to simplify data transfer between apps. Tom Hoffman's SIF ZIS has a lot of potential in this area.
NOTE/DISCLAIMER: I am active in DrupalEd -- not that it has any relevance to this post, but some might claim that my involvement in an OS project eliminates any possibility of objectivity