I will give my experience. However, I am not a guru when it comes to computers so take it with a grain of salt. The problem I have with my Vanilla Debian installation of Debian 12 with Gnome on an old Dell 755 Optiplex from 2008 is that if Gnome has Wayland and I click on either Thunderbird or Firefox, a black box shows up on the desktop and that is it. If i change it to Gnome with Xorg, Thunderbird and Firefox come up like normal. I do not know what would cause that, but it has been true for the last couple of Debian versions. I'm sure someone with more technical knowledge than I would know exactly the cause. The computer has a very old Nvidia Graphics Card which is no longer supported by Debian, and I believe that is part of the problem.