What about people who are missing fingers or perhaps don't have hands/the use of hands and are typing through a straw? (Any slashdotters out there in that situation?) Sure there are custom designed keyboards, and specialized software for that sort of thing, but when it comes down to it the only multi key combination that is difficult to work around not being able to do is shift+alpha unless you have caps lock of course. Caps lock makes it so that someone who can only type with a straw can have rudimentary use of any computer. (Except for Macs with the apple key + ctrl + shift + mouse click functions.)