A key point of this article is lipid nanoparticles. It's likely that they utilized GalNAc-LNP (N-acetylgalactosamine lipid nanoparticles) for treating liver diseases. GalNAc-LNPs are notable for their capacity to deliver therapeutics directly to liver cells, leveraging the liver's inherent uptake mechanisms. While this isn't explicitly mentioned, it may be included in the redacted sections of the protocol. This targeted delivery system has the potential to greatly improve the effectiveness of treatments for rare liver conditions, which frequently lack viable therapies. Unfortunately, its use may be restricted to liver-related genetic disorders. I'm not aware of another lipid conjugation that can target a specific part of the body. Regardless, this represents a significant advance.

I didn't realize you can't edit posts anymore. Regardless, you hit the main question that hasn't been answered. Will this produce better canidates. Drugs have a binding site. Can these AI methods determine the exact amino acid residues that are critical in the binding site and provide good suggestion on what to modify. Currently it is a semi-manual and computationally brute force method. Could AI take all the existing structure activity relationships we generated to better design a better drug. In theory yes, but I personally haven't seen it yet. I'm sure it has happened, but was it a one off hit or was it something more deep than that.

This article is not surprisingly light on details. It suggests an effort to expedite the process for a potential drug to progress from an initial screening hit, through the stages of refining medicinal chemistry properties during lead optimization, and ultimately becoming a drug candidate ready for preclinical trials. However, this accelerated process does not eliminate the necessity for preclinical trials to demonstrate safety and efficacy before proceeding to clinical trials.

With a strong password, you can plea the 5th and not self incriminate. This is not an option with biometrics.

Chances are your office buys its supplies from Staples.