Comment Sabayon (not the distro) and Pessulus (Score 1) 904
There are hundreds of comments here and I'm not going to read them all so I apologise if I'm repeating something somebody else has said, but the Gnome tools for locking down a desktop are Sabayon (as I said above, not the distro) and Pessulus.
Sabayon is a desktop user profile manager and Pessulus is a Gnome lockdown tool. Sadly neither seems to have been updated in the last 3 years, maybe they did the job they were designed for, but I know people were using them.