Retrospect, yes (Score 1)

I'm a principal engineer in the Retrospect team at EMC. Yes, we (as Dantz) were bought by EMC a couple of years back, but we're still alive and kicking.

Retrospect is alive and well, too. We have some exciting strategic plans and we're hiring senior engineers with system software experience.

Retrospect is well suited to the poster's issue. It has "proactive" backup for intermittently connected laptops, SQL backup, strong encryption and many other features that -- whoops, </sales-pitch>.