I've set up Android tablets for a number of family members and friends who had limited technological prowess, had very limited goals for what they wanted to be able to do and/or were intimidated by the interface and operation of a tablet. In each case the first thing I do is to replace the stock launcher with something that's more easily customizable. For tablets running Android 4,x I use Nova Launcher. For tablets running 2.x (which won't run Nova) I use Holo Launcher. I use these launchers because you can vary icon size, font size and other visual elements. Then I delete every home screen except one blank one. I disable the "dock" too, just for the sake of simplicity. I set up ONE home screen with a grid of maybe 3 columns by 5 rows, and I make my icons and fonts as large as I can that will still display clearly within that grid size (it's easy to see when you've made things too big). For anyone who finds the interface hard to read I'll go into Settings/Accessibility and make text larger (this setting changes ALL text, including on the display screens and in most apps). I custom build the home screen to fit the needs of my user but a generic example would probably have Dolphin Browser (basic operations like bookmarks are very intuitive), Gmail, theScore or ESPN for sports fans, Google Play Store, maybe YouTube. If they have certain web sites that they want to be sure they can get to I'll put an icon on the home screen that goes directly to those sites. Maybe they'd want the Kindle app, or Facebook, or Google Maps, maybe Calendar or Contacts, but I try to err on the side of simplicity for novice users. I'll drop on a Google Search widget and a Clock/Weather widget that looks colorful and I'll set a nice background photo that looks good but doesn't make things harder to read. In a lower corner I'll add an icon for Apps (having eliminated the Dock) and an icon for Settings. We're talking about tablets but if I was setting up a smartphone I'd have the essential call/text/camera icons on that lowest row as well. I'll spend some time with my novice user going over the layout and functions, make changes as needed and then "lock" the home screen so they can't accidentally delete something.
What I deliver to my user is a device that has easy access to ONLY what he/she says is needed (the Apps icon will always get you everything else). I want the user to feel as though they can master the functions they have and become comfortable with the interface (novice smartphone/tablet users often have never used a touch screen or swiped to navigate). As they become more familiar and more confident they, or I if needed, can effortlessly expand the displays and uses. A new user who feels comfortable and confident will use the device and, in time, likely want to learn more. A new user who feels intimidated and lost will get frustrated quickly and stuff the thing in a drawer.