jamie found an account in the NYTimes of the life and death of one of the most important figures in modern neuroscience, Henry Gustav Molaison — a man who could not form memories. Molaison became an amnesiac after a brain operation in 1953. Known worldwide as H.M., Molaison was studied intensively for 55 years. Dr. Brenda Milner, a psychologist from Montreal, was the first researcher to visit Molaison. In 1962 she authored a landmark study demonstrating that a part of Molaison's memory was fully intact. "The implications were enormous. Scientists saw that there were at least two systems in the brain for creating new memories. One, known as declarative memory, records names, faces and new experiences and stores them until they are consciously retrieved. ... Another system, commonly known as motor learning, is subconscious and depends on other brain systems. This explains why people can jump on a bike after years away from one and take the thing for a ride, or why they can pick up a guitar that they have not played in years and still remember how to strum it. Soon 'everyone wanted an amnesic to study,' Dr. Milner said..."

Jupix writes "It took Rockstar most of a year to port Grand Theft Auto IV to the PC, and while they claim this was because they wanted polish and quality with their PC release, it appears the result has been less than satisfactory. Players all over the internet are furious over numerous bugs in the release, ranging from nonfunctional internet registration and graphics glitches to completely inoperative installations. One of the game's largest retailers, Steam, has reportedly gone so far as to start handing out refunds to hordes of unsatisfied (and no doubt uncomfortably noisy) customers."

mattnyc99 writes "Esquire is running a a jaw-dropping profile of MacArthur genius Marc Roth in their annual Best and Brightest roundup, detailing how this gonzo DNA scientist (who also figured out how to diagnose lupus correctly) went from watching his infant daughter die to literally reincarnating animals. Inspired by NOVA and funded by DARPA, Roth has developed a serum for major biotech startup Ikaria that successfully accomplished 'suspended animation' — the closest we've ever come to simulating near-death experiences and then coming back to life. From the article: 'We don't know what life is, anyway. Not really. We just know what life does — it burns oxygen. It's a process of combustion. We're all just slow-burning candles, making our way through our allotment of precious O2 until it becomes our toxin, until we burn out, until we get old and die. But we live on 21 percent oxygen, just as we live at 37 degrees. They're related. Decrease the oxygen to 5 percent, we die. But, look, the concentration of oxygen in the blood that runs through our capillaries is only 2 or 3 percent. We're almost dead already! So what if we turn down the candle's need for oxygen? What if we dim the candle so much that we don't even have the energy to die?' " The writer Tom Junod engages in what Hunter Thompson once called "a failed but essentially noble experiment in pure gonzo journalism." If you can suspend your inner critic for a time, it's a fun ride.

Bethesda has announced that an editor for the Windows version of Fallout 3 will be coming in December. They also said the first additional downloadable content for the Windows and XBox 360 versions will follow in January. MTV's Multiplayer blog got a few more details from Bethesda's Pete Hines, who said additions to Fallout 3 will resemble the Oblivion expansion pack Knights of the Nine in size and scope. MTV then brought up the question of how early publishers should provide DLC, pointing to Fallout 3 and Fable II as examples of games for which the expansions were planned to go live only a few months after launch.

Mike Sheppard writes "I'm a graduate student in Statistics at Michigan State University and spent some time analyzing past US presidential elections to determine how close they truly were. The mathematical procedures of Linear Programming and 0-1 Integer Programming were used to find the optimal solution to the question: 'What is the smallest number of total votes that need to be switched from one candidate to another, and from which states, to affect the outcome of the election?' Because of the way the popular and electoral votes interact, the outcome of the analysis had some surprising and intriguing results. For example, in 2004, 57,787 votes would have given us President Kerry; and in 2000, 269 votes would have given us President Gore. In all there have been 12 US Presidential elections that were decided by less than a 1% margin; meaning if less than 1% of the voters in certain states had changed their mind to the other candidate the outcome of the election would have been different."