Might be lymphoma, possibly caused by chronic EBV. I've been told I have chronic EBV and to watch for certain signs that it could turn cancerous. But there's no hard data on how often that happens as there have not been any studies. The bigger concern is actually melanoma.
I believe it's one of the lymphoma's, H or non-H, but I don't know which one. And yea the skin cancer rates on transplants are a big deal too.
Anyways, being on the third kidney tells me that whoever this is has been on dialysis a few times.
They're actually one of the original infant dialysis patients, where they installed a shunt, and filled the abdomen with fluid, and then drained it back out. The original root cause was a congenital defect, a blockage that couldn't be imaged at the time. A day or two of dry diapers, and it was too late... I'm under the impression imaging has gotten so much better it would have been caught and a better outcome would likely happen today.
Regardless, about 5% of the time when people stop taking their anti-rejection drugs, nothing happens because for reasons we don't quite understand, somehow at some point their immune system accepted the graft.
Is there any correlation with family transplants? Someone on my wife's side of the family got a kidney from his Mom, and it was a really good match. He worked in a chemical plant and the stuff he was manufacturing turns out to be one of the worst kidney toxins I've ever researched, styrene. He went back to work and it took the new kidney out too. The settlement on that is apparently still taught in law school... But it led to kidney #2... They died of a heart attack caused by enlargement from cyclosporin dosing unknowns. (this was decades ago...)
Also something they likely told the patient but maybe not you, is that the half-life of a cadaverous kidney transplant is about 10 years, from any cause of loss of graft. The half-life of living donors is 20 years. It's not all about the immune system.
Yea, I'm a shoestring relative here on both of them. I think it got conveyed at some point but it skipped my mind.
I appreciate the info, I hope you continue in good health!
T