Comment Re:Paywall (Score 1) 93
That's not necessarily enough to implicate "poisons". All sorts of conditions were rare or functionally unheard of until Industrial Revolution periods, because our lives were rather closer to the conditions they evolved for (large amounts of time spent outdoors with a different mix of pathogens than you get in a fairly sterile indoor environment) until that point. Allergies, various autoimmune issues, asthma, and even nearsightedness were rare, less severe, or non-existent in the before times.
For the first three, the working theory ("hygiene hypothesis") is that, because our immune systems evolved to expect a certain level, and certain type, of disease in the environment, to calibrate the body's idea of what constitutes a dangerous pathogen, when we moved from "exposure to lots of digestive system pathogens and parasites" to "almost none of that, just lots of respiratory ailments that spread easily indoors" the immune system went haywire and either identified harmless things as harmful, or failed to even properly identify what constituted "self" vs. "other".
For nearsightedness, that's always existed, but it's gotten worse. Some of that is likely genetic; we developed cheap enough glasses and it became less important to have good eyes to pass on your genes, so the selective pressure to preserve genes for good vision largely vanished. But it's also because our eyes calibrate as children by looking at distant things in good lighting (that is, outdoors, in sunlight). When we moved indoors and stopped working and playing outside as much, the lighting got worse (you may think you use a lot of lights, but that's your eyes fooling you by adjusting to make indoors seem brighter; it's a tiny fraction of what natural sunlight provides), and we mostly looked at nearby things, and whoops, myopia becomes more common and more severe.
And of course, many disorders, like Parkinson's, are largely diseases of old age (typical age of onset for Parkinson's is 60), so in a world with lower life expectancy (yes, a lot of it was child mortality, but some of it was shorter lifespans even for those who survived childhood), the percentage of people who live long enough for Parkinson's to be a meaningful risk would be lower.
To be clear, I'm not arguing that Parkinson's isn't possibly triggered by an environmental toxin. Just that "it was only described recently" as evidence for "it must be caused by a brand new toxin" is overlooking the many, many changes we've made to the environment we live in over the past 200-odd years that cause all sorts of disorders in ways we still don't definitively understand the causation behind, or only very recently found explanations for.