Comment Benefits (there are some) (Score 2, Informative) 710
If you ever want to run an Itanium2 with Linux you'll need Redhat Advanced Server. And cough up the dough too. For both the machine and the software license. Intel did a deal with Redhat to give first shot at itanium2's for porting. And with an Itanium2 there is a lot of porting to be done.
I'd personaly go with an opteron myself. You dont need to reorganize your software for the architecture so it will run efficiently. Also you are not tied to Intels linux compilers which are pretty poor quality for the itanium2. Gcc has been ported to the itanium2, but it has not been optimized well yet. And Intels compiler is just very very buggy.