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Comment Re:And Yawn! (Score 1) 17

Besides, maybe with a little luck, MSFT will nickel-and-dime Adobe hard-core along the way, and they become victims of the same rental scheme they've inflicted on their own customer base. Couldn't happen to a more deserving company, really.

I'm also hoping Affinity will eat their lunch with reasonably priced software with perpetual licenses. So far they have excellent Photoshop and Illustrator alternatives for Mac, with a DTP and DAM package to come. Windows versions are on the way, with Designer (cf Illustrator) already in beta:

Comment Re:And after 1 year you will need to buy new car t (Score 1) 52

The earlier Nokia version of HERE for Android was very good for offline use - whole countries or large regions like US states were downloadable in one go as usefully searchable maps with SatNav routing, all for free. Google's limited offline capabilities looked pretty feeble in comparison. Now that the car companies have got hold of it and renamed it HERE WeGo, they've changed the interface to make it much more more oriented to providing turn-by-turn directions rather than map exploration, and long-term users are finding it slower and buggier, with a flakier offline mode:

Comment Re:Meanwhile the EU is saying... (Score 1) 315

If Labour campaigns under an "Elect us and Brexit won't happen as long as we're in charge." platform, then it's certainly possible that they could get a lot of support.

It won't, though. The current leader, Jeremy Corbyn, has been a Eurosceptic for most of his political life, and despite coming out (unconvincingly) for the party's established Remain policy before the referendum, did the bare minimum to promote it, and has since seemed content to follow through with Brexit. He's now facing a leadership challenge, but his faction, though it has little support in the parliamentary party, has comprehensively taken over the wider party and will very probably vote him straight back in. Polling suggests he has very little chance of winning a general election, however - his wildly popular Sanders-like status amongst party members is not reflected in the opinions of ordinary voters. Labour has lost its way at the worst possible time, when a truly effective opposition would be doing all it could to hold an unelected Prime Minister to account over a crisis precipitated by her predecessor's ill-advised attempt to resolve internal conflicts in the Conservative party.

Comment Re: Including this one? (Score 1) 349

'Defective by design' is exactly it. On a standard Windows/Office system everything is set up to make this error the default behaviour, and the problem with gene names is so prevalent that we include a warning about it in our genomics course. The typical situation is: some upstream tool generates a very long gene list (maybe with thousands of rows) in CSV format. So far so good. But then a naive user wants to do some simple manipulation of the data and double-clicks the file to open it. Its icon includes the Excel logo and, sure enough, Excel is registered as the default application for CSV files, so it opens as a spreadsheet in Excel. Everything seems to be fine - there's a nice column of gene symbols that all seem to be correct. But hundreds or thousands of rows further down, something looks like a date and has been 'helpfully' converted into one by Excel. At this point, you can't reverse the change by changing the data type of the column - the corruption has happened silently on import and will be permanent in any saved (even CSV) version of the file. The counterintuitive but correct way to deal with a genomics CSV file (if you're mad or uninformed enough to use Excel in the first place) is to open Excel first, then run a file import with the data type specified for each column (for gene symbols, you need 'text' rather than 'general'). The answer to all this is education (avoid Excel, but if you must use it, understand the dumb way it works), but would it kill Microsoft to change the default behaviour to something more sensible (this can hadly be the only use case where this is an issue), and to include a global setting to switch it off?

Comment Re:Well, crap (Score 1) 57

First check if you installed the clean version:

Otherwise, don't reboot yet, do a backup now, then follow the instructions from the link in the story above.

What the story doesn't mention is that MS helpfully deletes Classic Start Menu (well, moves it to Windows.old) when the Anniversary Update is installed, which is the only reason people were downloading a fresh copy of the Classic Shell installer rather than using the built-in update function (which wasn't affected by the malware).

Comment Re:The sheer scale of it (Score 1) 42

A human has about 4 billion base pairs, which are roughly 2 bits each, so that is 500 MB. You could fit that on a CDROM with room to spare. But humans share 99% of their DNA, so you would really only need to store the diffs. 1% is 5 MB.

A copy of the (haploid) reference genome encoded as 2 bits per base pair comes in at about 800MB:

Run that through something like Z-zip and you can store it in less that 640MB, so it will indeed fit on a CD. Each of us has a diploid genome, though (a copy from each parent), so you really need to store double that if you take no account of the high level of similarity between both copies. If we assume a known reference genome, however, the 'diffs' are as you suggest very small - one paper reports compression down to 4MB, small enough to email:

Lots of analyses are done with lists of variants with respect to a reference genome, but the raw data generally comes from 'next generation sequencing' platforms, where every base needs to be sequenced many times over before bases can be called confidently, and quality scores of base calls need to be stored. The raw data usually needs to be kept since alignment and variant calling algorithms are improving all the time. Storage requirements are something like 80GB+ compressed.

Comment Ash nazg durbatuluk (Score 1) 129

There will be 20 sizes available during its trial run where it will be available exclusively for employees and partners

Let me guess:

Three Rings for the Elven-kings under the sky,
Seven for the Dwarf-lords in their halls of stone,
Nine for Mortal Men doomed to die,
One for the Dark Lord on his dark throne
In the Land of Mordor where the Shadows lie.

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